Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50244756 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_512649 (CHEMBL969699) |
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Ki | 28±n/a nM |
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Citation | Eilfeld, A; González Tanarro, CM; Frizler, M; Sieler, J; Schulze, B; Gütschow, M Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides. Bioorg Med Chem16:8127-35 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50244756 |
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n/a |
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Name | BDBM50244756 |
Synonyms: | 2-(2,3,5,6-Tetrafluoropyridin-4-yl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | CHEMBL518500 |
Type | Small organic molecule |
Emp. Form. | C12H4F4N2O3S |
Mol. Mass. | 332.23 |
SMILES | Fc1nc(F)c(F)c(N2C(=O)c3ccccc3S2(=O)=O)c1F |
Structure |
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