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TargetBradykinin B1 receptor
LigandBDBM50244434
Substrate/Competitorn/a
Meas. Tech.ChEMBL_512956
Ki 59.9±n/a nM
Citation Biswas KAya TQian WPeterkin TAChen JJHuman JHungate RWKumar GArik LLester-Zeiner DBiddlecome GManning BHSun HDong HHuang MLoeloff RJohnson EJAskew BC Aryl sulfones as novel bradykinin B1 receptor antagonists for treatment of chronic pain. Bioorg Med Chem Lett 18:4764-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BK-1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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  Blast E-value cutoff:
BDBM50244434
n/a
NameBDBM50244434
Synonyms:(R)-4-(naphthalen-2-ylsulfonyl)-N-(6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)butanamide | CHEMBL488512
TypeSmall organic molecule
Emp. Form.C30H36N2O3S
Mol. Mass.504.683
SMILESO=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12 |r|
Structure
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