Ki Summary

Reaction Details

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Target

Rhodopsin

Ligand

BDBM50158383

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_513184 (CHEMBL977314)

IC50

15000±n/a nM

Citation

Taylor, CM; Barda, Y; Kisselev, OG; Marshall, GR Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem51:5297-303 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Rhodopsin

Name:

Rhodopsin

Synonyms:

OPSD_BOVIN | RHO

Type:

PROTEIN

Mol. Mass.:

39006.28

Organism:

Bos taurus

Description:

ChEMBL_513184

Residue:

348

Sequence:

MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLG
GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIP
EGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQES
ATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAV
YNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA

BDBM50158383

n/a

Name

BDBM50158383

Synonyms:

2-((8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl 4-bromobenzenesulfonate | 3,20-dioxopregn-4-en-21-yl 4-bromobenzenesulfonate | 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) | CHEMBL387152 | NSC-88915

Type

Small organic molecule

Emp. Form.

C27H33BrO5S

Mol. Mass.

549.517

SMILES

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 |r,t:8|

Structure