| Reaction Details |
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 | Report a problem with these data |
| Target | Ras guanyl-releasing protein 3 |
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| Ligand | BDBM50245023 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513189 (CHEMBL977319) |
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| Ki | 32±n/a nM |
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| Citation |  El Kazzouli, S; Lewin, NE; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins. J Med Chem51:5371-86 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ras guanyl-releasing protein 3 |
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| Name: | Ras guanyl-releasing protein 3 |
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| Synonyms: | GRP3 | GRP3_HUMAN | KIAA0846 | RAS guanyl releasing protein 3 | RASGRP3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78335.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1364407 |
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| Residue: | 690 |
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| Sequence: | MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
HAGVDVVDRGTEFELDQDEGEETRQDGEDG
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| BDBM50245023 |
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| n/a |
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| Name | BDBM50245023 |
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| Synonyms: | (Z)-(2-(hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylene)-tetrahydrofuran-2-yl)methyl 2-propylpentanoate | CHEMBL488707 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29NO5 |
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| Mol. Mass. | 411.4908 |
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| SMILES | CCCC(CCC)C(=O)OCC1(CO)C\C(=C\c2cnc3ccccc3c2)C(=O)O1 |
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| Structure | 
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