Ki Summary

Reaction Details

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Target

Ras guanyl-releasing protein 3

Ligand

BDBM50244481

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_513189 (CHEMBL977319)

3.3±n/a nM

Citation

El Kazzouli, S; Lewin, NE; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins. J Med Chem51:5371-86 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Ras guanyl-releasing protein 3

Name:

Ras guanyl-releasing protein 3

Synonyms:

GRP3 | GRP3_HUMAN | KIAA0846 | RAS guanyl releasing protein 3 | RASGRP3

Type:

PROTEIN

Mol. Mass.:

78335.20

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1364407

Residue:

690

Sequence:

MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
HAGVDVVDRGTEFELDQDEGEETRQDGEDG

BDBM50244481

n/a

Name

BDBM50244481

Synonyms:

(E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxo-tetrahydrofuran-2-yl)methyl 4-methoxybenzoate | CHEMBL488674

Type

Small organic molecule

Emp. Form.

C24H23NO6

Mol. Mass.

421.4425

SMILES

COc1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1

Structure