Ki Summary

Reaction Details

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Target

Gastric inhibitory polypeptide receptor

Ligand

BDBM50245057

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_513212 (CHEMBL977342)

IC50

98±n/a nM

Citation

Kodra, JT; Jørgensen, AS; Andersen, B; Behrens, C; Brand, CL; Christensen, IT; Guldbrandt, M; Jeppesen, CB; Knudsen, LB; Madsen, P; Nishimura, E; Sams, C; Sidelmann, UG; Pedersen, RA; Lynn, FC; Lau, J Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem51:5387-96 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastric inhibitory polypeptide receptor

Name:

Gastric inhibitory polypeptide receptor

Synonyms:

GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor

Type:

PROTEIN

Mol. Mass.:

53173.82

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1518286

Residue:

466

Sequence:

MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC

BDBM50245057

n/a

Name

BDBM50245057

Synonyms:

(R)-trans-3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(3-methyl-5-trifluoromethylphenyl)ureidomethyl]benzoylamino}-2-hydroxy-propionic acid | CHEMBL486651

Type

Small organic molecule

Emp. Form.

C30H38F3N3O5

Mol. Mass.

577.635

SMILES

Cc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)cc(c1)C(F)(F)F |r,wU:27.31,19.20,wD:24.24,(9.34,-6,;9.33,-4.46,;8,-3.69,;8.01,-2.15,;6.67,-1.38,;5.34,-2.15,;5.34,-3.69,;4,-1.38,;2.67,-2.16,;1.34,-1.39,;-0,-2.16,;-1.33,-1.39,;-1.33,.16,;-0,.93,;1.33,.16,;-2.67,.93,;-2.67,2.47,;-4,.15,;-5.33,.92,;-6.67,.15,;-6.67,-1.39,;-8,.92,;-8,2.46,;-9.34,.15,;4,.16,;5.34,.92,;5.34,2.46,;4.01,3.23,;2.67,2.46,;2.67,.92,;4.01,4.77,;4.01,6.32,;5.55,4.77,;2.47,4.76,;9.33,-1.38,;10.66,-2.14,;10.67,-3.68,;11.99,-1.36,;13.32,-.58,;12.77,-2.69,;11.21,-.03,)|

Structure