| Reaction Details |
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 | Report a problem with these data |
| Target | Gastric inhibitory polypeptide receptor |
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| Ligand | BDBM50244508 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513212 (CHEMBL977342) |
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| IC50 | 279±n/a nM |
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| Citation |  Kodra, JT; Jørgensen, AS; Andersen, B; Behrens, C; Brand, CL; Christensen, IT; Guldbrandt, M; Jeppesen, CB; Knudsen, LB; Madsen, P; Nishimura, E; Sams, C; Sidelmann, UG; Pedersen, RA; Lynn, FC; Lau, J Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem51:5387-96 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastric inhibitory polypeptide receptor |
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| Name: | Gastric inhibitory polypeptide receptor |
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| Synonyms: | GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53173.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1518286 |
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| Residue: | 466 |
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| Sequence: | MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
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| BDBM50244508 |
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| n/a |
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| Name | BDBM50244508 |
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| Synonyms: | (R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methoxy-5-trifluoromethylphenyl)ureidomethyl]-benzoylamino}-2-hydroxypropionic acid | CHEMBL509710 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32F3N3O6 |
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| Mol. Mass. | 611.6082 |
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| SMILES | COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)cc(c1)C(F)(F)F |r,t:33| |
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| Structure | 
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