Ki Summary

Reaction Details

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Target

Gastric inhibitory polypeptide receptor

Ligand

BDBM50244505

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_513212 (CHEMBL977342)

IC50

220±n/a nM

Citation

Kodra, JT; Jørgensen, AS; Andersen, B; Behrens, C; Brand, CL; Christensen, IT; Guldbrandt, M; Jeppesen, CB; Knudsen, LB; Madsen, P; Nishimura, E; Sams, C; Sidelmann, UG; Pedersen, RA; Lynn, FC; Lau, J Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem51:5387-96 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastric inhibitory polypeptide receptor

Name:

Gastric inhibitory polypeptide receptor

Synonyms:

GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor

Type:

PROTEIN

Mol. Mass.:

53173.82

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1518286

Residue:

466

Sequence:

MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC

BDBM50244505

n/a

Name

BDBM50244505

Synonyms:

(R)-trans-3-{4-[1-(4-tert-Butylcyclohexyl)-3-(3,5-dimethylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid | CHEMBL452067

Type

Small organic molecule

Emp. Form.

C30H41N3O5

Mol. Mass.

523.6636

SMILES

Cc1cc(C)cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)c1 |r,wU:30.34,22.23,wD:27.27,(41.34,-18.77,;40.01,-19.54,;40.02,-21.09,;38.69,-21.86,;38.69,-23.4,;37.35,-21.1,;37.36,-19.55,;36.02,-18.79,;34.69,-19.56,;34.69,-21.1,;33.36,-18.79,;32.03,-19.56,;30.69,-18.79,;29.35,-19.57,;28.02,-18.8,;28.02,-17.25,;29.35,-16.48,;30.68,-17.24,;26.69,-16.48,;26.69,-14.94,;25.35,-17.25,;24.02,-16.48,;22.69,-17.25,;22.69,-18.79,;21.35,-16.48,;21.35,-14.94,;20.02,-17.25,;33.36,-17.25,;34.69,-16.48,;34.7,-14.95,;33.36,-14.18,;32.03,-14.95,;32.02,-16.49,;33.37,-12.64,;33.36,-11.09,;34.91,-12.63,;31.83,-12.64,;38.68,-18.78,)|

Structure