Ki Summary

Reaction Details

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Target

Gastric inhibitory polypeptide receptor

Ligand

BDBM50244457

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_513212 (CHEMBL977342)

IC50

87±n/a nM

Citation

Kodra, JT; Jørgensen, AS; Andersen, B; Behrens, C; Brand, CL; Christensen, IT; Guldbrandt, M; Jeppesen, CB; Knudsen, LB; Madsen, P; Nishimura, E; Sams, C; Sidelmann, UG; Pedersen, RA; Lynn, FC; Lau, J Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem51:5387-96 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastric inhibitory polypeptide receptor

Name:

Gastric inhibitory polypeptide receptor

Synonyms:

GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor

Type:

PROTEIN

Mol. Mass.:

53173.82

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1518286

Residue:

466

Sequence:

MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC

BDBM50244457

n/a

Name

BDBM50244457

Synonyms:

(R)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-tert-butylcyclohexyl)ureidomethyl]-benzoylamino}-2-hydroxypropionic acid | CHEMBL499160

Type

Small organic molecule

Emp. Form.

C30H35F6N3O5

Mol. Mass.

631.6064

SMILES

CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,22.24,wD:7.10,(4.8,4.42,;4.81,2.87,;6.35,2.88,;3.27,2.87,;4.8,1.33,;6.14,.56,;6.13,-.98,;4.8,-1.74,;3.46,-.98,;3.47,.56,;4.8,-3.28,;3.47,-4.05,;2.13,-3.29,;.79,-4.06,;-.54,-3.29,;-.54,-1.74,;.79,-.97,;2.12,-1.74,;-1.87,-.97,;-1.87,.57,;-3.21,-1.74,;-4.54,-.97,;-5.87,-1.74,;-5.87,-3.28,;-7.21,-.97,;-7.21,.57,;-8.54,-1.74,;6.13,-4.05,;6.13,-5.59,;7.46,-3.28,;8.8,-4.05,;10.12,-3.27,;11.45,-4.03,;11.46,-5.58,;10.13,-6.35,;8.79,-5.59,;10.13,-7.89,;10.12,-9.43,;11.67,-7.9,;8.59,-7.9,;12.78,-3.26,;14.11,-2.47,;13.56,-4.58,;12,-1.93,)|

Structure