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TargetCathepsin K
LigandBDBM50244460
Substrate/Competitorn/a
Meas. Tech.ChEMBL_513250 (CHEMBL980886)
IC50 76±n/a nM
Citation Teno, NMasuya, KEhara, TKosaka, TMiyake, TIrie, OHitomi, YMatsuura, NUmemura, IIwasaki, GFukaya, HToriyama, KUchiyama, NNonomura, KSugiyama, IKometani, M Effect of cathepsin K inhibitors on bone resorption. J Med Chem51:5459-62 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CATK_RAT | Ctsk
Type:PROTEIN
Mol. Mass.:36798.82
Organism:Rattus norvegicus
Description:ChEMBL_633322
Residue:329
Sequence:
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVH
NLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSID
YRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGG
YMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVA
RVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGE
SWGNKGYVLLARNKNNACGITNLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50244460
n/a
NameBDBM50244460
Synonyms:7-(2,2-dimethylpropyl)-6-[(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL527883
TypeSmall organic molecule
Emp. Form.C20H25N7O2
Mol. Mass.395.4582
SMILESCC(C)(C)Cn1c(CN2C(=O)NC3(CCNCC3)C2=O)cc2cnc(nc12)C#N
Structure
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