Reaction Details |
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Target | Cannabinoid receptor 1 |
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Ligand | BDBM50253805 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_510960 (CHEMBL1003147) |
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IC50 | 7±n/a nM |
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Citation | Tseng, SL; Hung, MS; Chang, CP; Song, JS; Tai, CL; Chiu, HH; Hsieh, WP; Lin, Y; Chung, WL; Kuo, CW; Wu, CH; Chu, CM; Tung, YS; Chao, YS; Shia, KS Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists. J Med Chem51:5397-412 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 1 |
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Name: | Cannabinoid receptor 1 |
Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52868.96 |
Organism: | Homo sapiens (Human) |
Description: | P21554 |
Residue: | 472 |
Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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BDBM50253805 |
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n/a |
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Name | BDBM50253805 |
Synonyms: | CHEMBL460132 | N-(Azepan-1-yl)-1-(2,4-dichlorophenyl)-4-methyl-5-(5-(pent-1-ynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide |
Type | Small organic molecule |
Emp. Form. | C26H28Cl2N4OS |
Mol. Mass. | 515.498 |
SMILES | CCCC#Cc1ccc(s1)-c1c(C)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCCC1 |
Structure |
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