| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50202412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535281 (CHEMBL982606) |
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| Ki | 1600±n/a nM |
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| Citation |  Guo, Q; Chandrasekhar, J; Ihle, D; Wustrow, DJ; Chenard, BL; Krause, JE; Hutchison, A; Alderman, D; Cheng, C; Cortright, D; Broom, D; Kershaw, MT; Simmermacher-Mayer, J; Peng, Y; Hodgetts, KJ 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists. Bioorg Med Chem Lett18:5027-31 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1R | B1bkr | BK-1 receptor | BKRB1_RAT | Bdkrb1 | Bkr | Bradykinin B1 receptor | KB1 | Kinin B1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38389.97 |
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| Organism: | RAT |
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| Description: | B1 BRADYKININ BDKRB1 RAT::P97583 |
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| Residue: | 337 |
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| Sequence: | MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSF
FLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLC
RVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSI
PTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLR
GQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEIT
DLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL
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| BDBM50202412 |
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| n/a |
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| Name | BDBM50202412 |
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| Synonyms: | 3-Chloro-3'-fluoro-4'-((R)-1-{[1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarbonyl]-amino}-ethyl)-biphenyl-2-carboxylic acid methyl ester | CHEMBL232943 | methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClF4N2O4 |
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| Mol. Mass. | 486.844 |
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| SMILES | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(CC2)NC(=O)C(F)(F)F)c(F)c1 |r| |
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| Structure | 
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