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TargetDual specificity mitogen-activated protein kinase kinase 1
LigandBDBM50264742
Substrate/Competitorn/a
Meas. Tech.ChEMBL_496718 (CHEMBL1005355)
IC50 1800±n/a nM
Citation George, DFriedman, MAllen, HArgiriadi, MBarberis, CBischoff, AClabbers, ACusack, KDixon, RFix-Stenzel, SGordon, TJanssen, BJia, YMoskey, MQuinn, CSalmeron, JAWishart, NWoller, KYu, Z Discovery of thieno[2,3-c]pyridines as potent COT inhibitors. Bioorg Med Chem Lett18:4952-5 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 1
Name:Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2
Type:Other Protein Type
Mol. Mass.:43439.03
Organism:Homo sapiens (Human)
Description:Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates.
Residue:393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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  Blast E-value cutoff:
BDBM50264742
n/a
NameBDBM50264742
Synonyms:2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphenyl-4-yloxy)thieno[2,3-c]pyridine | CHEMBL490423
TypeSmall organic molecule
Emp. Form.C21H12F3N5OS
Mol. Mass.439.413
SMILESFC(F)(F)c1ccc(cc1)-c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Structure
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