Reaction Details |
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Target | Dual specificity mitogen-activated protein kinase kinase 1 |
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Ligand | BDBM50264742 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_496718 (CHEMBL1005355) |
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IC50 | 1800±n/a nM |
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Citation | George, D; Friedman, M; Allen, H; Argiriadi, M; Barberis, C; Bischoff, A; Clabbers, A; Cusack, K; Dixon, R; Fix-Stenzel, S; Gordon, T; Janssen, B; Jia, Y; Moskey, M; Quinn, C; Salmeron, JA; Wishart, N; Woller, K; Yu, Z Discovery of thieno[2,3-c]pyridines as potent COT inhibitors. Bioorg Med Chem Lett18:4952-5 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity mitogen-activated protein kinase kinase 1 |
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Name: | Dual specificity mitogen-activated protein kinase kinase 1 |
Synonyms: | Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2 |
Type: | Other Protein Type |
Mol. Mass.: | 43439.03 |
Organism: | Homo sapiens (Human) |
Description: | Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates. |
Residue: | 393 |
Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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BDBM50264742 |
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n/a |
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Name | BDBM50264742 |
Synonyms: | 2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphenyl-4-yloxy)thieno[2,3-c]pyridine | CHEMBL490423 |
Type | Small organic molecule |
Emp. Form. | C21H12F3N5OS |
Mol. Mass. | 439.413 |
SMILES | FC(F)(F)c1ccc(cc1)-c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1 |
Structure |
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