| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 8 |
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| Ligand | BDBM50265277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496717 (CHEMBL1005354) |
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| IC50 | 2200±n/a nM |
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| Citation |  George, D; Friedman, M; Allen, H; Argiriadi, M; Barberis, C; Bischoff, A; Clabbers, A; Cusack, K; Dixon, R; Fix-Stenzel, S; Gordon, T; Janssen, B; Jia, Y; Moskey, M; Quinn, C; Salmeron, JA; Wishart, N; Woller, K; Yu, Z Discovery of thieno[2,3-c]pyridines as potent COT inhibitors. Bioorg Med Chem Lett18:4952-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 8 |
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| Name: | Mitogen-activated protein kinase kinase kinase 8 |
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| Synonyms: | C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 52916.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41279 |
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| Residue: | 467 |
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| Sequence: | MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
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| BDBM50265277 |
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| n/a |
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| Name | BDBM50265277 |
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| Synonyms: | 4-phenoxy-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridine | CHEMBL524468 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9N5OS |
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| Mol. Mass. | 295.319 |
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| SMILES | O(c1ccccc1)c1cncc2sc(cc12)-c1nnn[nH]1 |
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| Structure | 
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