| Reaction Details |
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 | Report a problem with these data |
| Target | Egl nine homolog 1 |
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| Ligand | BDBM50264177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535338 (CHEMBL983464) |
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| IC50 | 400±n/a nM |
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| Citation |  Frohn, M; Viswanadhan, V; Pickrell, AJ; Golden, JE; Muller, KM; Bürli, RW; Biddlecome, G; Yoder, SC; Rogers, N; Dao, JH; Hungate, R; Allen, JR Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors. Bioorg Med Chem Lett18:5023-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Egl nine homolog 1 |
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| Name: | Egl nine homolog 1 |
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| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
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| Type: | Protein |
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| Mol. Mass.: | 46035.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9GZT9 |
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| Residue: | 426 |
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| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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| BDBM50264177 |
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| n/a |
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| Name | BDBM50264177 |
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| Synonyms: | 2-(2-methyl-1-phenyl-1H-imidazo[4,5-c]pyridine-4-carboxamido)acetic acid | CHEMBL491425 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14N4O3 |
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| Mol. Mass. | 310.3074 |
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| SMILES | Cc1nc2c(nccc2n1-c1ccccc1)C(=O)NCC(O)=O |
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| Structure | 
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