| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
|---|
| Ligand | BDBM8054 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_535435 (CHEMBL985261) |
|---|
| IC50 | 10000±n/a nM |
|---|
| Citation |  Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors. Bioorg Med Chem Lett18:4972-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PLK1 |
|---|
| Name: | Serine/threonine-protein kinase PLK1 |
|---|
| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 68277.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53350 |
|---|
| Residue: | 603 |
|---|
| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
|
|
|
|---|
| BDBM8054 |
|---|
| n/a |
|---|
| Name | BDBM8054 |
|---|
| Synonyms: | 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 25 | 4-({4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl}amino)phenol | 4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2-ylamino]phenol | 4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2-ylamino]phenol, 6 | CHEMBL47590 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15N5OS |
|---|
| Mol. Mass. | 313.378 |
|---|
| SMILES | CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
