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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H3 receptor | ||
| Ligand | BDBM50263325 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_535494 (CHEMBL986121) | ||
| IC50 | 18±n/a nM | ||
| Citation |  Jitsuoka, M; Tsukahara, D; Ito, S; Tanaka, T; Takenaga, N; Tokita, S; Sato, N Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorg Med Chem Lett18:5101-6 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H3 receptor | |||
| Name: | Histamine H3 receptor | ||
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 48691.47 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50263325 | |||
| n/a | |||
| Name | BDBM50263325 | ||
| Synonyms: | CHEMBL507921 | trans-6'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H32N2O4 | ||
| Mol. Mass. | 400.5112 | ||
| SMILES | COc1ccc2C(=O)O[C@]3(CC[C@@H](CC3)C(=O)N(C)CCN3CCCCC3)c2c1 |r,wU:9.8,wD:12.15,(-5.23,-6.51,;-6.07,-7.8,;-5.38,-9.18,;-6.22,-10.48,;-5.52,-11.85,;-3.99,-11.93,;-3.02,-13.14,;-3.42,-14.62,;-1.57,-12.59,;-1.65,-11.04,;-1.65,-9.5,;-.32,-8.73,;1.01,-9.5,;1.01,-11.04,;-.32,-11.81,;2.35,-8.74,;2.35,-7.2,;3.68,-9.51,;5.01,-8.75,;3.67,-11.05,;5,-11.83,;5,-13.37,;3.66,-14.12,;3.65,-15.66,;4.98,-16.44,;6.32,-15.67,;6.33,-14.13,;-3.14,-10.64,;-3.83,-9.26,)| | ||
| Structure | 
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