Reaction Details | |||
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Target | Histamine H3 receptor | ||
Ligand | BDBM50263357 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_535494 (CHEMBL986121) | ||
IC50 | 3.6±n/a nM | ||
Citation | Jitsuoka, M; Tsukahara, D; Ito, S; Tanaka, T; Takenaga, N; Tokita, S; Sato, N Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorg Med Chem Lett18:5101-6 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Histamine H3 receptor | |||
Name: | Histamine H3 receptor | ||
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 48691.47 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. | ||
Residue: | 445 | ||
Sequence: |
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BDBM50263357 | |||
n/a | |||
Name | BDBM50263357 | ||
Synonyms: | CHEMBL478434 | trans-7'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide | ||
Type | Small organic molecule | ||
Emp. Form. | C23H32N2O4 | ||
Mol. Mass. | 400.5112 | ||
SMILES | COc1cccc2C(=O)O[C@]3(CC[C@@H](CC3)C(=O)N(C)CCN3CCCCC3)c12 |r,wU:10.9,wD:13.16,(14.73,-6.83,;15.42,-8.21,;14.58,-9.5,;13.03,-9.41,;12.19,-10.71,;12.89,-12.08,;14.42,-12.17,;15.39,-13.37,;14.99,-14.86,;16.84,-12.82,;16.76,-11.28,;16.76,-9.74,;18.09,-8.96,;19.42,-9.74,;19.42,-11.28,;18.09,-12.04,;20.76,-8.97,;20.76,-7.43,;22.09,-9.75,;23.42,-8.98,;22.08,-11.29,;23.41,-12.06,;23.41,-13.6,;22.07,-14.36,;22.06,-15.89,;23.39,-16.67,;24.73,-15.91,;24.74,-14.36,;15.27,-10.87,)| | ||
Structure |