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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H1 receptor | ||
| Ligand | BDBM50263323 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_535495 (CHEMBL986122) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Jitsuoka, M; Tsukahara, D; Ito, S; Tanaka, T; Takenaga, N; Tokita, S; Sato, N Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorg Med Chem Lett18:5101-6 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H1 receptor | |||
| Name: | Histamine H1 receptor | ||
| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 55808.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. | ||
| Residue: | 487 | ||
| Sequence: |
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| BDBM50263323 | |||
| n/a | |||
| Name | BDBM50263323 | ||
| Synonyms: | CHEMBL514217 | trans-3'-Oxo-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H30N2O3 | ||
| Mol. Mass. | 370.4852 | ||
| SMILES | CN(CCN1CCCCC1)C(=O)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:15.19,wD:12.12,(3.45,4.02,;2.11,3.26,;2.11,1.72,;3.44,.94,;3.44,-.6,;2.1,-1.35,;2.09,-2.88,;3.42,-3.67,;4.76,-2.9,;4.77,-1.36,;.78,4.03,;.79,5.57,;-.55,3.27,;-1.88,4.04,;-3.21,3.27,;-3.21,1.73,;-1.88,.96,;-.55,1.73,;-3.14,.18,;-4.58,-.37,;-4.98,-1.85,;-5.55,.84,;-7.09,.92,;-7.79,2.29,;-6.94,3.6,;-5.4,3.51,;-4.7,2.13,)| | ||
| Structure | 
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