Reaction Details | |||
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Target | Histamine H4 receptor | ||
Ligand | BDBM50263324 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_535497 (CHEMBL986124) | ||
IC50 | >10000±n/a nM | ||
Citation | Jitsuoka, M; Tsukahara, D; Ito, S; Tanaka, T; Takenaga, N; Tokita, S; Sato, N Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorg Med Chem Lett18:5101-6 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Histamine H4 receptor | |||
Name: | Histamine H4 receptor | ||
Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44517.02 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Binding assays were using CHO cells stably expressing hH4R receptors. | ||
Residue: | 390 | ||
Sequence: |
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BDBM50263324 | |||
n/a | |||
Name | BDBM50263324 | ||
Synonyms: | CHEMBL513893 | trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide | ||
Type | Small organic molecule | ||
Emp. Form. | C23H32N2O4 | ||
Mol. Mass. | 400.5112 | ||
SMILES | COc1ccc2c(c1)C(=O)O[C@]21CC[C@@H](CC1)C(=O)N(C)CCN1CCCCC1 |r,wU:11.11,wD:14.19,(9.71,4.04,;10.41,2.67,;11.95,2.59,;12.79,3.89,;14.34,3.8,;15.03,2.43,;14.18,1.13,;12.64,1.22,;15.15,-.07,;14.75,-1.56,;16.6,.48,;16.52,2.02,;16.52,3.56,;17.85,4.34,;19.18,3.56,;19.18,2.02,;17.85,1.26,;20.51,4.33,;20.52,5.87,;21.85,3.55,;23.18,4.32,;21.84,2.01,;23.17,1.24,;23.17,-.3,;21.83,-1.06,;21.82,-2.59,;23.15,-3.37,;24.49,-2.61,;24.5,-1.06,)| | ||
Structure |