Reaction Details |
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Target | Melanocortin receptor 4 |
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Ligand | BDBM50189008 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_538608 (CHEMBL1027398) |
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Ki | 11±n/a nM |
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Citation | Tian, X; Switzer, AG; Derose, SA; Mishra, RK; Solinsky, MG; Mumin, RN; Ebetino, FH; Jayasinghe, LR; Webster, ME; Colson, AO; Crossdoersen, D; Pinney, BB; Farmer, JA; Dowty, ME; Obringer, CM; Cruze, CA; Burklow, ML; Suchanek, PM; Dong, L; Dirr, MK; Sheldon, RJ; Wos, JA Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents. J Med Chem51:6055-66 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanocortin receptor 4 |
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Name: | Melanocortin receptor 4 |
Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
Type: | Enzyme |
Mol. Mass.: | 36949.50 |
Organism: | Homo sapiens (Human) |
Description: | P32245 |
Residue: | 332 |
Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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BDBM50189008 |
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n/a |
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Name | BDBM50189008 |
Synonyms: | (S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propanoyl)-3-(2-guanidinoethyl)-2-oxopiperazin-1-yl)-N-methyl-3-(naphthalen-2-yl)propanamide | (S)-2-[(S)-4-[(R)-2-Amino-3-(4-fluoro-phenyl)-propionyl]-3-(2-guanidino-ethyl)-2-oxo-piperazin-1-yl]-N-methyl-3-naphthalen-2-yl-propionamide | CHEMBL213566 |
Type | Small organic molecule |
Emp. Form. | C30H36FN7O3 |
Mol. Mass. | 561.6503 |
SMILES | [#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc2ccccc2c1)-[#7]-1-[#6]-[#6]-[#7](-[#6@@H](-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6]-1=O)-[#6](=O)-[#6@H](-[#7])-[#6]-c1ccc(F)cc1 |r| |
Structure |
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