Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMelatonin receptor type 1B
LigandBDBM50263662
Substrate/Competitorn/a
Meas. Tech.ChEMBL_535636 (CHEMBL987964)
Ki 0.28±n/a nM
Citation Poissonnier-Durieux, SEttaoussi, MPérès, BBoutin, JAAudinot, VBennejean, CDelagrange, PCaignard, DHRenard, PBerthelot, PLesieur, DYous, S Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands. Bioorg Med Chem16:8339-48 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melatonin receptor type 1B
Name:Melatonin receptor type 1B
Synonyms:MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:Enzyme
Mol. Mass.:40203.54
Organism:Homo sapiens (Human)
Description:P49286
Residue:362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50263662
n/a
NameBDBM50263662
Synonyms:CHEMBL476341 | N-[2-(3-(3-Hydroxymethylphenyl)-7-methoxynaphth-1-yl)ethyl]butyramide
TypeSmall organic molecule
Emp. Form.C24H27NO3
Mol. Mass.377.4761
SMILESCCCC(=O)NCCc1cc(cc2ccc(OC)cc12)-c1cccc(CO)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: