Reaction Details |
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Target | Melatonin receptor type 1B |
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Ligand | BDBM50263662 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_535636 (CHEMBL987964) |
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Ki | 0.28±n/a nM |
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Citation | Poissonnier-Durieux, S; Ettaoussi, M; Pérès, B; Boutin, JA; Audinot, V; Bennejean, C; Delagrange, P; Caignard, DH; Renard, P; Berthelot, P; Lesieur, D; Yous, S Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands. Bioorg Med Chem16:8339-48 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melatonin receptor type 1B |
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Name: | Melatonin receptor type 1B |
Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
Type: | Enzyme |
Mol. Mass.: | 40203.54 |
Organism: | Homo sapiens (Human) |
Description: | P49286 |
Residue: | 362 |
Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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BDBM50263662 |
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n/a |
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Name | BDBM50263662 |
Synonyms: | CHEMBL476341 | N-[2-(3-(3-Hydroxymethylphenyl)-7-methoxynaphth-1-yl)ethyl]butyramide |
Type | Small organic molecule |
Emp. Form. | C24H27NO3 |
Mol. Mass. | 377.4761 |
SMILES | CCCC(=O)NCCc1cc(cc2ccc(OC)cc12)-c1cccc(CO)c1 |
Structure |
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