Reaction Details |
| Report a problem with these data |
Target | 1-deoxy-D-xylulose-5-phosphate synthase |
---|
Ligand | BDBM50263925 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_535725 (CHEMBL989742) |
---|
IC50 | 14000±n/a nM |
---|
Citation | Mao, J; Eoh, H; He, R; Wang, Y; Wan, B; Franzblau, SG; Crick, DC; Kozikowski, AP Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett18:5320-3 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
1-deoxy-D-xylulose-5-phosphate synthase |
---|
Name: | 1-deoxy-D-xylulose-5-phosphate synthase |
Synonyms: | DXS_MYCTU | dxs |
Type: | PROTEIN |
Mol. Mass.: | 67882.02 |
Organism: | Mycobacterium tuberculosis |
Description: | ChEMBL_1441273 |
Residue: | 638 |
Sequence: | MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDS
PHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSY
ADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIAASRRPVIIVVNDNGRSYAPT
IGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVP
IDPATGQATKVAGPGWTATFSDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFD
VGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVLDRAGITG
SDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDI
SALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPV
SDGVRELAVQHKLLVTLEDNGVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSE
VLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
|
|
|
BDBM50263925 |
---|
n/a |
---|
Name | BDBM50263925 |
Synonyms: | 5-benzyl-3-(4-chlorophenyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | CHEMBL521577 |
Type | Small organic molecule |
Emp. Form. | C20H13ClF3N3O |
Mol. Mass. | 403.785 |
SMILES | FC(F)(F)c1[nH]n2c(nc(Cc3ccccc3)cc2=O)c1-c1ccc(Cl)cc1 |
Structure |
|