Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM50253470

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_539669 (CHEMBL1028977)

1200±n/a nM

Citation

Chen, J; Collins, GT; Zhang, J; Yang, CY; Levant, B; Woods, J; Wang, S Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile. J Med Chem51:5905-8 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

50931.60

Organism:

Rattus norvegicus (rat)

Description:

P61169

Residue:

444

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC

BDBM50253470

n/a

Name

BDBM50253470

Synonyms:

CHEMBL494509 | Naphthalene-2-carboxylic acid (4-{2-[((S)-2-amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-(2-cyclohexyl-ethyl)-amino]-ethyl}-cyclohexyl)-amide

Type

Small organic molecule

Emp. Form.

C34H46N4OS

Mol. Mass.

558.82

SMILES

Nc1nc2CC[C@@H](Cc2s1)N(CCC1CCCCC1)CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1 |r,wU:21.23,wD:6.11,24.30,(14.81,-38.39,;16.35,-38.39,;17.26,-37.13,;18.75,-37.61,;20.08,-36.84,;21.42,-37.62,;21.42,-39.17,;20.08,-39.94,;18.75,-39.17,;17.26,-39.65,;22.75,-39.94,;22.75,-41.48,;24.08,-42.25,;24.08,-43.79,;22.74,-44.55,;22.74,-46.08,;24.07,-46.86,;25.41,-46.1,;25.41,-44.55,;24.09,-39.17,;25.42,-39.94,;26.76,-39.18,;26.75,-37.64,;28.09,-36.87,;29.42,-37.65,;29.41,-39.19,;28.08,-39.95,;30.76,-36.88,;32.09,-37.65,;32.09,-39.19,;33.42,-36.88,;34.75,-37.66,;36.09,-36.89,;36.08,-35.35,;37.41,-34.58,;37.42,-33.04,;36.07,-32.27,;34.75,-33.04,;34.75,-34.58,;33.42,-35.35,)|

Structure