| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil collagenase |
|---|
| Ligand | BDBM26526 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_497405 (CHEMBL1002946) |
|---|
| Ki | 257±n/a nM |
|---|
| Citation |  Georgiadis, D; Yiotakis, A Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem16:8781-94 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil collagenase |
|---|
| Name: | Neutrophil collagenase |
|---|
| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53413.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22894 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
|
|
|
|---|
| BDBM26526 |
|---|
| n/a |
|---|
| Name | BDBM26526 |
|---|
| Synonyms: | (2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide | BMCL181958 Compound 1 | CHEMBL148169 | IK682 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27N3O4 |
|---|
| Mol. Mass. | 433.4996 |
|---|
| SMILES | C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
