| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50265078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_497414 (CHEMBL1002955) |
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| Ki | 0.190000±n/a nM |
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| Citation |  Georgiadis, D; Yiotakis, A Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem16:8781-94 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50265078 |
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| n/a |
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| Name | BDBM50265078 |
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| Synonyms: | (4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hydroxy)phosphoryl)-2-((3-(3'-chlorobiphenyl-4-yl)isoxazol-5-yl)methyl)propanamido)-4-carboxybutanamido)-5-oxopentanoic acid | CHEMBL507420 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H35BrClN4O10P |
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| Mol. Mass. | 818.004 |
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| SMILES | NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1cc(no1)-c1ccc(cc1)-c1cccc(Cl)c1)CP(O)(=O)c1ccc(Br)cc1 |r| |
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| Structure | 
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