Reaction Details |
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Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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Ligand | BDBM50183715 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_492682 (CHEMBL953112) |
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Ki | 0.350000±n/a nM |
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Citation | Georgiadis, D; Yiotakis, A Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem16:8781-94 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Disintegrin and metalloproteinase domain-containing protein 17 |
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Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
Synonyms: | A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme |
Type: | Metalloprotease |
Mol. Mass.: | 12197.99 |
Organism: | Sus scrofa (pig) |
Description: | Partially purified TACE was obtained from porcine spleen. |
Residue: | 112 |
Sequence: | MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
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BDBM50183715 |
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n/a |
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Name | BDBM50183715 |
Synonyms: | CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-tetrahydro-2H-pyran-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide | N-(4-(2-(hydroxyamino)-2-oxoethyl)tetrahydro-2H-pyran-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide |
Type | Small organic molecule |
Emp. Form. | C25H27N3O5 |
Mol. Mass. | 449.499 |
SMILES | Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCOCC2)c2ccccc2n1 |
Structure |
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