Reaction Details |
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Target | Tyrosine-protein kinase Lck |
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Ligand | BDBM50263516 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_535872 (CHEMBL994992) |
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IC50 | 13±n/a nM |
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Citation | Zhang, G; Ren, P; Gray, NS; Sim, T; Liu, Y; Wang, X; Che, J; Tian, SS; Sandberg, ML; Spalding, TA; Romeo, R; Iskandar, M; Chow, D; Martin Seidel, H; Karanewsky, DS; He, Y Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I. Bioorg Med Chem Lett18:5618-21 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lck |
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Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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BDBM50263516 |
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n/a |
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Name | BDBM50263516 |
Synonyms: | CHEMBL450092 | N4-(6-(2-(2-chloro-6-methylphenylamino)-1H-benzo[d]imidazol-1-yl)pyrimidin-4-yl)-2-methyl-N6-(2-morpholinoethyl)pyrimidine-4,6-diamine |
Type | Small organic molecule |
Emp. Form. | C29H31ClN10O |
Mol. Mass. | 571.076 |
SMILES | Cc1nc(NCCN2CCOCC2)cc(Nc2cc(ncn2)-n2c(Nc3c(C)cccc3Cl)nc3ccccc23)n1 |
Structure |
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