Reaction Details |
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Target | Oxysterols receptor LXR-beta |
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Ligand | BDBM50252940 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_539729 (CHEMBL1032355) |
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IC50 | 30±n/a nM |
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Citation | Chao, EY; Caravella, JA; Watson, MA; Campobasso, N; Ghisletti, S; Billin, AN; Galardi, C; Wang, P; Laffitte, BA; Iannone, MA; Goodwin, BJ; Nichols, JA; Parks, DJ; Stewart, E; Wiethe, RW; Williams, SP; Smallwood, A; Pearce, KH; Glass, CK; Willson, TM; Zuercher, WJ; Collins, JL Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem51:5758-65 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxysterols receptor LXR-beta |
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Name: | Oxysterols receptor LXR-beta |
Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50978.79 |
Organism: | Homo sapiens (Human) |
Description: | P55055 |
Residue: | 460 |
Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM50252940 |
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n/a |
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Name | BDBM50252940 |
Synonyms: | 4-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)methyl]-2,6-dichlorophenol | CHEMBL493241 | GSK-9772 |
Type | Small organic molecule |
Emp. Form. | C20H19Cl2F6NO2 |
Mol. Mass. | 490.267 |
SMILES | CCCCN(Cc1cc(Cl)c(O)c(Cl)c1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F |
Structure |
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