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TargetCyclin-dependent kinase 2
LigandBDBM7672
Substrate/Competitorn/a
Meas. Tech.ChEMBL_536407
IC50<3±n/a nM
Citation Anderson MAndrews DMBarker AJBrassington CABreed JByth KFCulshaw JDFinlay MRFisher EMcMiken HHGreen CPHeaton DWNash IANewcombe NJOakes SEPauptit RARoberts AStanway JJThomas APTucker JAWalker MWeir HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:5487-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM7672
n/a
NameBDBM7672
Synonyms:4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl)amino]-N-methylbenzene-1-sulfonamide | CHEMBL520003 | Imidazo[1,2-b]pyridazine deriv. 2b
TypeSmall organic molecule
Emp. Form.C17H15N7O2S
Mol. Mass.381.412
SMILESCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3cccnn23)cc1
Structure
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