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TargetG1/S-specific cyclin-D3
LigandBDBM50246253
Substrate/Competitorn/a
Meas. Tech.ChEMBL_536593 (CHEMBL988883)
IC50 21±n/a nM
Citation Anderson, MAndrews, DMBarker, AJBrassington, CABreed, JByth, KFCulshaw, JDFinlay, MRFisher, EMcMiken, HHGreen, CPHeaton, DWNash, IANewcombe, NJOakes, SEPauptit, RARoberts, AStanway, JJThomas, APTucker, JAWalker, MWeir, HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett18:5487-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G1/S-specific cyclin-D3
Name:G1/S-specific cyclin-D3
Synonyms:CCND3 | CCND3_HUMAN
Type:Enzyme
Mol. Mass.:32521.90
Organism:Homo sapiens (Human)
Description:P30281
Residue:292
Sequence:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50246253
n/a
NameBDBM50246253
Synonyms:4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine | AZD-5438 | CHEMBL488436
TypeSmall organic molecule
Emp. Form.C18H21N5O2S
Mol. Mass.371.457
SMILESCC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1
Structure
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