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TargetCyclin-dependent kinase 2
LigandBDBM50274743
Substrate/Competitorn/a
Meas. Tech.ChEMBL_536407 (CHEMBL992478)
IC50 68±n/a nM
Citation Anderson, MAndrews, DMBarker, AJBrassington, CABreed, JByth, KFCulshaw, JDFinlay, MRFisher, EMcMiken, HHGreen, CPHeaton, DWNash, IANewcombe, NJOakes, SEPauptit, RARoberts, AStanway, JJThomas, APTucker, JAWalker, MWeir, HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett18:5487-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50274743
n/a
NameBDBM50274743
Synonyms:CHEMBL458547 | N-(2-methoxyethyl)-4-(4-(1,2,4-trimethyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)benzenesulfonamide
TypeSmall organic molecule
Emp. Form.C19H24N6O3S
Mol. Mass.416.497
SMILESCOCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2c(C)nc(C)n2C)cc1
Structure
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