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TargetCyclin-dependent kinase 2
LigandBDBM50274625
Substrate/Competitorn/a
Meas. Tech.ChEMBL_536407
IC50 8±n/a nM
Citation Anderson MAndrews DMBarker AJBrassington CABreed JByth KFCulshaw JDFinlay MRFisher EMcMiken HHGreen CPHeaton DWNash IANewcombe NJOakes SEPauptit RARoberts AStanway JJThomas APTucker JAWalker MWeir HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:5487-92 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50274625
n/a
NameBDBM50274625
Synonyms:4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(propylsulfonyl)phenyl)pyrimidin-2-amine | CHEMBL485240
TypeSmall organic molecule
Emp. Form.C20H25N5O2S
Mol. Mass.399.51
SMILESCCCS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1
Structure
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