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TargetMitogen-activated protein kinase 14
LigandBDBM50253153
Substrate/Competitorn/a
Meas. Tech.ChEMBL_539857 (CHEMBL1024853)
IC50 2±n/a nM
Citation Herberich, BCao, GQChakrabarti, PPFalsey, JRPettus, LRzasa, RMReed, ABReichelt, ASham, KThaman, MWurz, RPXu, SZhang, DHsieh, FLee, MRSyed, RLi, VGrosfeld, DPlant, MHHenkle, BSherman, LMiddleton, SWong, LMTasker, AS Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J Med Chem51:6271-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM50253153
n/a
NameBDBM50253153
Synonyms:CHEMBL495330 | N-Cyclopropyl-4-methyl-3-(1-phenyl-6-phthalazinyl)benzamide
TypeSmall organic molecule
Emp. Form.C25H21N3O
Mol. Mass.379.4537
SMILESCc1ccc(cc1-c1ccc2c(nncc2c1)-c1ccccc1)C(=O)NC1CC1
Structure
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