| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gastrin-releasing peptide receptor |
|---|
| Ligand | BDBM50275902 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_496873 (CHEMBL998542) |
|---|
| EC50 | 0.06±n/a nM |
|---|
| Citation |  Carlton, DL; Collin-Smith, LJ; Daniels, AJ; Deaton, DN; Goetz, AS; Laudeman, CP; Littleton, TR; Musso, DL; Morgan, RJ; Szewczyk, JR; Zhang, C Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead. Bioorg Med Chem Lett18:5451-5 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gastrin-releasing peptide receptor |
|---|
| Name: | Gastrin-releasing peptide receptor |
|---|
| Synonyms: | Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43214.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Bombesin 2 GRPR 0::P30550 |
|---|
| Residue: | 384 |
|---|
| Sequence: | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
|
|
|
|---|
| BDBM50275902 |
|---|
| n/a |
|---|
| Name | BDBM50275902 |
|---|
| Synonyms: | CHEMBL525577 | D-Phe-Gln-Trp-Ala-Val-b-Ala-His-Phe-Nle-NH2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C57H76N14O10 |
|---|
| Mol. Mass. | 1117.3011 |
|---|
| SMILES | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
