| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50275552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496886 (CHEMBL998555) |
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| IC50 | 200±n/a nM |
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| Citation |  Cheung, M; Harris, PA; Badiang, JG; Peckham, GE; Chamberlain, SD; Alberti, MJ; Jung, DK; Harris, SS; Bramson, NH; Epperly, AH; Stimpson, SA; Peel, MR The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors. Bioorg Med Chem Lett18:5428-30 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50275552 |
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| n/a |
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| Name | BDBM50275552 |
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| Synonyms: | 2-(4-fluorophenyl)-3-(pyridin-4-yl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine | CHEMBL487781 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H11F4N3 |
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| Mol. Mass. | 357.3044 |
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| SMILES | Fc1ccc(cc1)-c1nn2cc(ccc2c1-c1ccncc1)C(F)(F)F |
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| Structure | 
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