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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H3 receptor | ||
| Ligand | BDBM50274691 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_537241 (CHEMBL981856) | ||
| IC50 | 813±n/a nM | ||
| Citation |  Nagase, T; Mizutani, T; Sekino, E; Ishikawa, S; Ito, S; Mitobe, Y; Miyamoto, Y; Yoshimoto, R; Tanaka, T; Ishihara, A; Takenaga, N; Tokita, S; Sato, N Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists. J Med Chem51:6889-901 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H3 receptor | |||
| Name: | Histamine H3 receptor | ||
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 48691.47 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50274691 | |||
| n/a | |||
| Name | BDBM50274691 | ||
| Synonyms: | CHEMBL485604 | trans-2-Methyl-3-(4-([4-(1-pyrrolidinyl)cyclohexyl]oxy)phenyl)-4(3H)-quinazolinone | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H29N3O2 | ||
| Mol. Mass. | 403.5167 | ||
| SMILES | Cc1nc2ccccc2c(=O)n1-c1ccc(O[C@H]2CC[C@@H](CC2)N2CCCC2)cc1 |r,wU:17.18,wD:20.25,(33.03,-37.04,;31.7,-37.81,;30.36,-37.04,;29.03,-37.82,;27.69,-37.06,;26.36,-37.83,;26.36,-39.38,;27.7,-40.15,;29.03,-39.37,;30.37,-40.13,;30.37,-41.67,;31.71,-39.36,;33.04,-40.13,;33.04,-41.67,;34.37,-42.43,;35.71,-41.66,;37.04,-42.42,;38.37,-41.65,;38.35,-40.11,;39.69,-39.34,;41.03,-40.11,;41.03,-41.65,;39.7,-42.42,;42.36,-39.34,;43.76,-39.96,;44.79,-38.82,;44.02,-37.49,;42.52,-37.81,;35.7,-40.11,;34.36,-39.35,)| | ||
| Structure | 
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