| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell receptor CD22 |
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| Ligand | BDBM50274236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_537287 (CHEMBL985383) |
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| IC50 | 683330±n/a nM |
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| Citation |  Abdu-Allah, HH; Tamanaka, T; Yu, J; Zhuoyuan, L; Sadagopan, M; Adachi, T; Tsubata, T; Kelm, S; Ishida, H; Kiso, M Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors. J Med Chem51:6665-81 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell receptor CD22 |
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| Name: | B-cell receptor CD22 |
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| Synonyms: | CD22 | CD22_HUMAN | SIGLEC2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95348.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_727026 |
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| Residue: | 847 |
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| Sequence: | MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFH
NPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLR
MESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEG
VPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKH
TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT
KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL
PTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK
KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNT
TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ
FFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM
SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQ
GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQG
LQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAES
SEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV
DYVILKH
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| BDBM50274236 |
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| n/a |
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| Name | BDBM50274236 |
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| Synonyms: | 2-(trimethylsilyl)ethyl (5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2,6)-beta-D-galactopyranoside) | CHEMBL456656 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H45NO15Si |
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| Mol. Mass. | 663.7401 |
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| SMILES | CC(=O)N[C@@H]1[C@@H](O)C[C@@](OC[C@H]2O[C@@H](Oc3ccc(OCC[Si](C)(C)C)cc3)[C@H](O)[C@@H](O)[C@H]2O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r| |
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| Structure | 
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