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TargetBcl2-associated agonist of cell death
LigandBDBM50274315
Substrate/Competitorn/a
Meas. Tech.ChEMBL_537289 (CHEMBL985385)
Ki 14±n/a nM
Citation Park, CMBruncko, MAdickes, JBauch, JDing, HKunzer, AMarsh, KCNimmer, PShoemaker, ARSong, XTahir, SKTse, CWang, XWendt, MDYang, XZhang, HFesik, SWRosenberg, SHElmore, SW Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins. J Med Chem51:6902-15 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl2-associated agonist of cell death
Name:Bcl2-associated agonist of cell death
Synonyms:BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:PROTEIN
Mol. Mass.:18393.69
Organism:Homo sapiens (Human)
Description:ChEMBL_478760
Residue:168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
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BDBM50274315
n/a
NameBDBM50274315
Synonyms:(R)-4-(4-((4'-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)phenylsulfonyl)benzamide | CHEMBL508864
TypeSmall organic molecule
Emp. Form.C42H46ClN5O3S2
Mol. Mass.768.429
SMILESCN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r|
Structure
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