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TargetCyclin-dependent kinase 2
LigandBDBM50246415
Substrate/Competitorn/a
Meas. Tech.ChEMBL_557990 (CHEMBL965585)
IC50 14±n/a nM
Citation Fan, JFahr, BStockett, DChan, ECheeti, SSerafimova, ILu, YPham, PWalker, DHHoch, UChoong, IC Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio. Bioorg Med Chem Lett18:6236-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50246415
n/a
NameBDBM50246415
Synonyms:CHEMBL454645 | N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-6-methylpiperidine-3-carboxamide
TypeSmall organic molecule
Emp. Form.C18H26N4O2S2
Mol. Mass.394.555
SMILESCC1CCC(CN1)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Structure
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