Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50246415 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_557990 (CHEMBL965585) |
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IC50 | 14±n/a nM |
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Citation | Fan, J; Fahr, B; Stockett, D; Chan, E; Cheeti, S; Serafimova, I; Lu, Y; Pham, P; Walker, DH; Hoch, U; Choong, IC Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio. Bioorg Med Chem Lett18:6236-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50246415 |
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n/a |
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Name | BDBM50246415 |
Synonyms: | CHEMBL454645 | N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-6-methylpiperidine-3-carboxamide |
Type | Small organic molecule |
Emp. Form. | C18H26N4O2S2 |
Mol. Mass. | 394.555 |
SMILES | CC1CCC(CN1)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 |
Structure |
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