| Reaction Details |
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 | Report a problem with these data |
| Target | P2Y purinoceptor 1 |
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| Ligand | BDBM50245983 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_558004 (CHEMBL965599) |
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| Ki | 70±n/a nM |
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| Citation |  Morales-Ramos, AI; Mecom, JS; Kiesow, TJ; Graybill, TL; Brown, GD; Aiyar, NV; Davenport, EA; Kallal, LA; Knapp-Reed, BA; Li, P; Londregan, AT; Morrow, DM; Senadhi, S; Thalji, RK; Zhao, S; Burns-Kurtis, CL; Marino, JP Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett18:6222-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2Y purinoceptor 1 |
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| Name: | P2Y purinoceptor 1 |
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| Synonyms: | ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42090.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47900 |
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| Residue: | 373 |
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| Sequence: | MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
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| BDBM50245983 |
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| n/a |
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| Name | BDBM50245983 |
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| Synonyms: | (2R,3S,4S)-2-Ethyl-3-methyl-N-[3,5-(chloro)phenyl]-4-(phenylamino)-3,4-dihydro-1(2H)-quinolinecarboxamide | (2R,3S,4S)-N-(3,5-dichlorophenyl)-2-ethyl-3-methyl-4-(phenylamino)-3,4-dihydroquinoline-1(2H)-carboxamide | CHEMBL462373 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25Cl2N3O |
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| Mol. Mass. | 454.392 |
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| SMILES | CC[C@@H]1[C@@H](C)[C@H](Nc2ccccc2)c2ccccc2N1C(=O)Nc1cc(Cl)cc(Cl)c1 |r| |
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| Structure | 
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