Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM12578 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_538311 (CHEMBL1036745) |
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IC50 | 4.1±n/a nM |
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Citation | Simoni, D; Gebbia, N; Invidiata, FP; Eleopra, M; Marchetti, P; Rondanin, R; Baruchello, R; Provera, S; Marchioro, C; Tolomeo, M; Marinelli, L; Limongelli, V; Novellino, E; Kwaasi, A; Dunford, J; Buccheri, S; Caccamo, N; Dieli, F Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism. J Med Chem51:6800-7 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM12578 |
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n/a |
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Name | BDBM12578 |
Synonyms: | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid |
Type | Small organic molecule |
Emp. Form. | C5H10N2O7P2 |
Mol. Mass. | 272.0896 |
SMILES | OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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