| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Ligand | BDBM50275933 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_492916 (CHEMBL945304) |
|---|
| Ki | 20±n/a nM |
|---|
| Citation |  Murineddu, G; Murruzzu, C; Curzu, MM; Chelucci, G; Gotti, C; Gaimarri, A; Legnani, L; Toma, L; Pinna, GA Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett18:6147-50 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56502.44 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q05941 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
|
|
|
|---|
| BDBM50275933 |
|---|
| n/a |
|---|
| Name | BDBM50275933 |
|---|
| Synonyms: | 3-(6-chloropyridin-3-yl)-6-methyl-3,6-diazabicyclo[3.1.1]heptane | CHEMBL470573 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H14ClN3 |
|---|
| Mol. Mass. | 223.702 |
|---|
| SMILES | CN1C2CC1CN(C2)c1ccc(Cl)nc1 |THB:8:6:1:3| |
|---|
| Structure | 
|
|---|
Search and Browse
