| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
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| Ligand | BDBM50216315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_492918 (CHEMBL945306) |
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| Ki | 0.018±n/a nM |
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| Citation |  Murineddu, G; Murruzzu, C; Curzu, MM; Chelucci, G; Gotti, C; Gaimarri, A; Legnani, L; Toma, L; Pinna, GA Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett18:6147-50 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-4 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
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| Synonyms: | ACHA4_RAT | Acra4 | Cholinergic, Nicotinic Alpha4Beta2 | Cholinergic, Nicotinic Alpha4Beta4 | Chrna4 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha4beta2 nAChR) | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Neuronal acetylcholine receptor subunit alpha-4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 70196.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P09483 |
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| Residue: | 630 |
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| Sequence: | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAAC
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| BDBM50216315 |
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| n/a |
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| Name | BDBM50216315 |
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| Synonyms: | (1R,4R)-2-(6-chloro-3-pyridinyl)-2,5-diazabicyclo[2.2.1]-heptane | (1S,4S)-2-(6-chloro-3-pyridinyl)-2,5-diazabicyclo[2.2.1]-heptane | 2-(6-chloropyridin-3-yl)-2,5-diazabicyclo[2.2.1]heptane | CHEMBL245243 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12ClN3 |
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| Mol. Mass. | 209.675 |
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| SMILES | Clc1ccc(cn1)N1CC2CC1CN2 |TLB:4:7:10:12.13| |
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| Structure | 
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