Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50275358 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_492922 (CHEMBL945310) |
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Ki | 1500±n/a nM |
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Citation | Farmer, LJ; Bemis, G; Britt, SD; Cochran, J; Connors, M; Harrington, EM; Hoock, T; Markland, W; Nanthakumar, S; Taslimi, P; Ter Haar, E; Wang, J; Zhaveri, D; Salituro, FG Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK). Bioorg Med Chem Lett18:6231-5 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50275358 |
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n/a |
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Name | BDBM50275358 |
Synonyms: | (2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyrimidin-4-yl)thiazol-4-yl)methanol | CHEMBL485731 |
Type | Small organic molecule |
Emp. Form. | C16H13F3N4OS |
Mol. Mass. | 366.361 |
SMILES | Cc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F |
Structure |
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