| Reaction Details |
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 | Report a problem with these data |
| Target | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Ligand | BDBM50246539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_558191 (CHEMBL962325) |
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| IC50 | 1249±n/a nM |
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| Citation |  Bunnage, ME; Mathias, JP; Wood, A; Miller, D; Street, SD Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule. Bioorg Med Chem Lett18:6033-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Synonyms: | PDE6A | PDE6A_CANLF | PDEA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99670.72 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_558191 |
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| Residue: | 861 |
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| Sequence: | MGEVTAEQVEKFLDSNIIFAKQYYNLRYRAKVISDMLGAKEAAVDFSNYHSLSSVEESEI
IFDLLRDFQENLQAERCIFNVMKKLCFLLQADRMSLFMYRVRNGIAELATRLFNVHKDAV
LEECLVAPDSEIVFPLDMGVVGHVAHSKKIANVVNTEEDEHFCDFVDTLTEYQTKNILAS
PIMNGKDVVAVIMAVNKVDEPHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLAQFLGWSVLNPDTYESMNRLENRKDIFQDMVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQGELPDAEKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDTKMKALEEEKQKQQTAKQGAAGD
QPGGNPSPAGGAPASKSCCIQ
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| BDBM50246539 |
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| n/a |
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| Name | BDBM50246539 |
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| Synonyms: | (R)-3-ethyl-5-(2-(1-methoxypropan-2-yloxy)-5-(4-propylpiperazin-1-ylsulfonyl)pyridin-3-yl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | CHEMBL460294 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H35N7O5S |
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| Mol. Mass. | 533.644 |
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| SMILES | CCCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| |
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| Structure | 
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