Reaction Details |
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Target | Histone deacetylase 3 |
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Ligand | BDBM50232034 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_493108 (CHEMBL940371) |
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IC50 | 7300±n/a nM |
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Citation | Methot, JL; Hamblett, CL; Mampreian, DM; Jung, J; Harsch, A; Szewczak, AA; Dahlberg, WK; Middleton, RE; Hughes, B; Fleming, JC; Wang, H; Kral, AM; Ozerova, N; Cruz, JC; Haines, B; Chenard, M; Kenific, CM; Secrist, JP; Miller, TA SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett18:6104-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 3 |
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Name: | Histone deacetylase 3 |
Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
Type: | Enzyme |
Mol. Mass.: | 48829.55 |
Organism: | Homo sapiens (Human) |
Description: | O15379 |
Residue: | 428 |
Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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BDBM50232034 |
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n/a |
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Name | BDBM50232034 |
Synonyms: | CHEMBL256440 | N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide |
Type | Small organic molecule |
Emp. Form. | C16H13N3OS |
Mol. Mass. | 295.359 |
SMILES | Nc1ccc(cc1NC(=O)c1cccnc1)-c1cccs1 |
Structure |
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