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TargetHistone deacetylase 1
LigandBDBM50275887
Substrate/Competitorn/a
Meas. Tech.ChEMBL_493106
IC50 8±n/a nM
Citation Methot JLHamblett CLMampreian DMJung JHarsch ASzewczak AADahlberg WKMiddleton REHughes BFleming JCWang HKral AMOzerova NCruz JCHaines BChenard MKenific CMSecrist JPMiller TA SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett 18:6104-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:HD1 | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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  Blast E-value cutoff:
BDBM50275887
n/a
NameBDBM50275887
Synonyms:CHEMBL470582 | N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-(methylsulfonyl)-2,8-diazaspiro[4.5]decan-8-yl)nicotinamide
TypeSmall organic molecule
Emp. Form.C25H29N5O3S2
Mol. Mass.511.659
SMILESCS(=O)(=O)N1CCC2(C1)CCN(CC2)c1ccc(cn1)C(=O)Nc1cc(ccc1N)-c1cccs1
Structure
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