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TargetHistone deacetylase 3
LigandBDBM50275768
Substrate/Competitorn/a
Meas. Tech.ChEMBL_493108 (CHEMBL940371)
IC50 340000±n/a nM
Citation Methot, JLHamblett, CLMampreian, DMJung, JHarsch, ASzewczak, AADahlberg, WKMiddleton, REHughes, BFleming, JCWang, HKral, AMOzerova, NCruz, JCHaines, BChenard, MKenific, CMSecrist, JPMiller, TA SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett18:6104-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 3
Name:Histone deacetylase 3
Synonyms:HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:Enzyme
Mol. Mass.:48829.55
Organism:Homo sapiens (Human)
Description:O15379
Residue:428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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  Blast E-value cutoff:
BDBM50275768
n/a
NameBDBM50275768
Synonyms:CHEMBL499776 | N-(2-aminophenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide
TypeSmall organic molecule
Emp. Form.C20H25N5O
Mol. Mass.351.4454
SMILESNc1ccccc1NC(=O)c1ccc(nc1)N1CCC2(CCNC2)CC1
Structure
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