| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin II |
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| Ligand | BDBM50273736 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_536036 (CHEMBL991606) |
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| Ki | 25±n/a nM |
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| Citation |  Hidaka, K; Kimura, T; Ruben, AJ; Uemura, T; Kamiya, M; Kiso, A; Okamoto, T; Tsuchiya, Y; Hayashi, Y; Freire, E; Kiso, Y Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem16:10049-60 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin II |
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| Name: | Plasmepsin II |
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| Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
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| Type: | Enzyme |
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| Mol. Mass.: | 51482.09 |
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| Organism: | Plasmodium falciparum |
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| Description: | P46925 |
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| Residue: | 453 |
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| Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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| BDBM50273736 |
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| n/a |
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| Name | BDBM50273736 |
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| Synonyms: | (R)-N-[(1S,2R)-2-Hydroxyindan-1-yl]-3-[(2S,3S)-3-(4-nitrophenoxyacetyl)amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | CHEMBL500010 | KNI-10256 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H36N4O8S |
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| Mol. Mass. | 648.726 |
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| SMILES | CC1(C)SCN([C@@H]1C(=O)N[C@@H]1[C@H](O)Cc2ccccc12)C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)COc1ccc(cc1)[N+]([O-])=O |r| |
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| Structure | 
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